Hematopoietic stimulants in the treatment and prevention of graft-versus-host disease

Conditioning regimens prior to hematopoietic stem cell transplantation (HSCT) are often accompanied by a period of aplasia characterized severe neutropenia, anemia, and thrombocytopenia. Long-term antibacterial immunosuppressive therapy in patients with graft-versus-host disease (GVHD) exacerbates depression. Colony-stimulating factors, erythropoietins, thrombopoietin receptor agonists used correct hematological dysfunction these patients. However, drugs have side effects, their stimulating effect, as rule, is limited one the lineages. At same time, after HSCT, for prevention treatment disorders against background GVHD, it necessary use that promote restoration all lines. Inducers Toll- NOD-like receptors, stimulators emergency hematopoiesis, can be considered promising this category These compounds include bacterial derivatives sulfated poly(oligo)saccharides capable which allows us consider them stimulants hematopoiesis immune status GVHD.